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One‐Pot Selective Functionalization of Nitrogen‐Containing Heterocycles with N ‐tosylhydrazones and Amines
Author(s) -
Naret Timothée,
Bzeih Tourin,
Retailleau Pascal,
Alami Mouad,
Hamze Abdallah
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701374
Subject(s) - chemistry , surface modification , nitrogen , combinatorial chemistry , organic chemistry , reaction conditions , catalysis
A new one‐pot reaction between N ‐tosylhydrazones, nitrogen‐containing heterocycles and amines has been developed. Depending on the reaction conditions chosen, the C−C or C−N bond formation has occurred as a first step controlling the functionalization of the heterocycle. A library of highly substituted heterocycles was then synthesized in moderate to excellent yields.

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