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Organocatalyzed Enantioselective Aldol and Henry Reactions Starting from Benzylic Alcohols
Author(s) -
AlegreRequena Juan V.,
MarquésLópez Eugenia,
Herrera Raquel P.
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701351
Subject(s) - aldol reaction , chemistry , enantioselective synthesis , organic chemistry , nitroaldol reaction , catalysis , organocatalysis
Pioneering aldol and Henry reactions starting from benzylic‐type alcohols are described. The aldol reaction has been successfully performed following a one‐pot strategy starting from alcohols, while the Henry reaction has been carried out following a sequential protocol for the first time. In both processes, enantiomerically enriched products were obtained with good yields and high enantioselectivities. We have also demonstrated that in reactions sensitive to small amounts of acid the use of alcohols instead of aldehydes could be a good solution for improving the results of these reactions.