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Merging Gold Catalysis and Brønsted Acid Catalysis for the Synthesis of Tetrahydrobenzo[ b ][1,8]naphthyridines
Author(s) -
Yi Ruxia,
Li Xincheng,
Wan Boshun
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701323
Subject(s) - chemistry , catalysis , brønsted–lowry acid–base theory , modular design , combinatorial chemistry , stereochemistry , organic chemistry , computer science , operating system
A gold(I)/Brønsted acid‐catalyzed cyclization of 2‐azidobenzaldehydes with 3‐aza‐1,6‐enynes has been developed for the synthesis of tetrahydrobenzo[ b ][1,8]naphthyridine derivatives. This protocol enabled the modular synthesis of tetracyclic heterocycles in one operation with water and nitrogen gas as the byproducts.