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Copper/Iron‐Cocatalyzed Cascade Perfluoroalkylation/Cyclization of 1,6‐Enynes with Iodoperfluoroalkanes
Author(s) -
Xia XiaoFeng,
Yu Jipan,
Wang Dawei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701258
Subject(s) - chemistry , reagent , benzofuran , combinatorial chemistry , cascade , double bond , copper , organic chemistry , medicinal chemistry , chromatography
A copper/iron‐cocatalyzed fluoroalkylative cyclization of 1,6‐enynes with readily available iodoperfluoroalkanes reagents for the synthesis of the corresponding fluoroalkylated pyrrolidines and benzofuran derivatives is reported. This novel protocol provides a mild method for the construction of C sp 3 ‐CF 2 and exocyclic double bonds in one step with high regio‐ and stereo‐selectivities.