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Distal Functional Group Migration for Visible‐light Induced Carbo‐difluoroalkylation/monofluoroalkylation of Unactivated Alkenes
Author(s) -
Yu Jiajia,
Wang Dongping,
Xu Yan,
Wu Zhen,
Zhu Chen
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701229
Subject(s) - chemistry , functional group , alkyl , photocatalysis , visible spectrum , group (periodic table) , combinatorial chemistry , organic chemistry , catalysis , polymer , physics , optoelectronics
A general and practical protocol for elusive carbo‐difluoroalkylation/ monofluoroalkylation of unactivated alkenes based on the distal functional group migration is described. A portfolio of functional groups including heteroaryl, imino, formyl, and alkynyl groups showcase the migratory aptitude. In combination with visible‐light photocatalysis, a broad range of di‐ and mono‐fluorinated alkyl ketones are readily obtained in synthetically useful yields under mild reaction conditions.

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