Distal Functional Group Migration for Visible‐light Induced Carbo‐difluoroalkylation/monofluoroalkylation of Unactivated Alkenes | Zendy

Yu Jiajia | Zendy; Wang Dongping | Zendy; Xu Yan | Zendy; Wu Zhen | Zendy; Zhu Chen | Zendy

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Distal Functional Group Migration for Visible‐light Induced Carbo‐difluoroalkylation/monofluoroalkylation of Unactivated Alkenes

Author(s) -

Yu Jiajia,

Wang Dongping,

Xu Yan,

Wu Zhen,

Zhu Chen

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201701229

Subject(s) - chemistry , functional group , alkyl , photocatalysis , visible spectrum , group (periodic table) , combinatorial chemistry , organic chemistry , catalysis , polymer , physics , optoelectronics

A general and practical protocol for elusive carbo‐difluoroalkylation/ monofluoroalkylation of unactivated alkenes based on the distal functional group migration is described. A portfolio of functional groups including heteroaryl, imino, formyl, and alkynyl groups showcase the migratory aptitude. In combination with visible‐light photocatalysis, a broad range of di‐ and mono‐fluorinated alkyl ketones are readily obtained in synthetically useful yields under mild reaction conditions.

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