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Lewis Acid‐Catalyzed Reductive Amination of Aldehydes and Ketones with N , N ‐Dimethylformamide as Dimethylamino Source, Reductant and Solvent
Author(s) -
Yang Luo,
Lin Jie,
Kang Lei,
Zhou Wang,
Ma DaYou
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701221
Subject(s) - chemistry , dimethylformamide , reductive amination , catalysis , solvent , yield (engineering) , zinc , amination , substrate (aquarium) , organic chemistry , lewis acids and bases , combinatorial chemistry , materials science , oceanography , metallurgy , geology
A practical zinc acetate dihydrate‐catalyzed reductive amination of various carbonyl compounds with N , N ‐dimethylformamide (DMF) as dimethylamino (Me 2 N) source, reductant and solvent has been developed. This reaction shows broad substrate scope, good functional group tolerance, avoids the need for a pressure‐proof reactor and column chromatographic isolation operations and gives up to 98% yield, to make it an attractive method for the preparation of tertiary N , N ‐dimethylamines.