Lewis Acid‐Catalyzed Reductive Amination of Aldehydes and Ketones with  N , N ‐Dimethylformamide as Dimethylamino Source, Reductant and Solvent | Zendy

Yang Luo | Zendy; Lin Jie | Zendy; Kang Lei | Zendy; Zhou Wang | Zendy; Ma DaYou | Zendy

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Lewis Acid‐Catalyzed Reductive Amination of Aldehydes and Ketones with N , N ‐Dimethylformamide as Dimethylamino Source, Reductant and Solvent

Author(s) -

Yang Luo,

Lin Jie,

Kang Lei,

Zhou Wang,

Ma DaYou

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201701221

Subject(s) - chemistry , dimethylformamide , reductive amination , catalysis , solvent , yield (engineering) , zinc , amination , substrate (aquarium) , organic chemistry , lewis acids and bases , combinatorial chemistry , materials science , oceanography , metallurgy , geology

A practical zinc acetate dihydrate‐catalyzed reductive amination of various carbonyl compounds with N , N ‐dimethylformamide (DMF) as dimethylamino (Me 2 N) source, reductant and solvent has been developed. This reaction shows broad substrate scope, good functional group tolerance, avoids the need for a pressure‐proof reactor and column chromatographic isolation operations and gives up to 98% yield, to make it an attractive method for the preparation of tertiary N , N ‐dimethylamines.

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