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Enantioselective Synthesis of β‐Aminotetralins via Chiral Phosphoric Acid‐catalyzed Reductive Amination of β‐Tetralones
Author(s) -
Park Do Young,
Kim KyungHee,
Cheon CheolHong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701198
Subject(s) - chemistry , reductive amination , enantioselective synthesis , tetralones , phosphoric acid , catalysis , combinatorial chemistry , amination , organic chemistry , organic synthesis , hydride , hydrogen
Abstract A new protocol for the synthesis of chiral β‐aminotetralins has been developed via chiral phosphoric acid‐catalyzed asymmetric reductive amination of β‐tetralones using a Hantzsch ester as an organic hydride donor. Various chiral β‐aminotetralins were obtained in good yields with good to high enantioselectivities. Furthermore, the utility of our new protocol was successfully demonstrated in the enantioselective synthesis of rotigotine.