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Pd/Mn Bimetallic Relay Catalysis for Aerobic Aldoxime Dehydration to Nitriles
Author(s) -
Zhang Dongliang,
Huang Yaping,
Zhang Erlei,
Yi Rong,
Chen Chao,
Yu Lei,
Xu Qing
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701154
Subject(s) - chemistry , nitrile , catalysis , bimetal , bimetallic strip , acetonitrile , dehydration , organic chemistry , combinatorial chemistry , photochemistry , biochemistry
Abstract A Pd/Mn bimetal system was found to be an effective catalyst for dehydration of aldoximes to the useful nitriles under mild aerobic conditions. Different to the known metal‐catalyzed aldoxime dehydration reactions, this reaction very possibly proceeded via an alternative mechanism of Pd/Mn bimetal relay catalysis involving a Mn‐catalyzed aerobic oxidation of aldoximes to nitrile oxides by air and a Pd‐catalyzed oxygen transfer from the nitrile oxides to the solvent acetonitrile. This method tolerates a variety of substrates including sterically bulky ones and also the natural product derivative.