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Palladium‐catalysed O ‐Allylation of α‐Hydroxyphosphonates: An Expedient Entry into Phosphono‐oxaheterocycles
Author(s) -
Kerim Mansour Dolé,
Cattoen Martin,
Fincias Nicolas,
Dos Santos Aurélie,
Arseniyadis Stellios,
El Kaïm Laurent
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701150
Subject(s) - chemistry , palladium , ring closing metathesis , metathesis , ring (chemistry) , combinatorial chemistry , catalysis , salt metathesis reaction , stereochemistry , organic chemistry , polymer , polymerization
We report here an unprecedented palladium‐catalysed O ‐allylation of α‐hydroxyphosphonates. The method was eventually included in a sequential Pudovik/Tsuji‐Trost type O ‐allylation/Ring‐Closing Metathesis to afford a variety of phosphorylated heterocycles of various sizes ranging from 5 to 16 starting from readily available aldehydes.