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Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides
Author(s) -
Ma Wenbo,
Weng Zhengyun,
Rogge Torben,
Gu Linghui,
Lin Jiafu,
Peng Ai,
Luo Xiang,
Gou Xiaojun,
Ackermann Lutz
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701147
Subject(s) - chemistry , ruthenium , metalation , catalysis , substrate (aquarium) , electrophile , selectivity , combinatorial chemistry , electrophilic substitution , organic chemistry , oceanography , geology
Ruthenium‐catalyzed C−H chalcogenations of anilides with readily available diselenides and disulfides have been achieved. Our strategy features ample substrate scope, affording the mono‐ ortho selenylated and thiolated anilides with complete site selectivity control and high catalytic efficacy. Detailed mechanistic studies provide strong support for a facile base‐assisted internal electrophilic substitution (BIES) metalation event.