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Palladium‐Catalyzed Cross‐Coupling/Annulation Cascade for Synthesis of 9‐Hydroxy and 9‐Aminofluorenes.
Author(s) -
François Benjamin,
Szczubelek Luc,
Berrée Fabienne,
Roisnel Thierry,
Carboni Bertrand
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701146
Subject(s) - annulation , palladium , intermolecular force , tandem , catalysis , cascade , chemistry , hydrogen bond , sequence (biology) , coupling (piping) , cascade reaction , combinatorial chemistry , stereochemistry , organic chemistry , molecule , materials science , biochemistry , chromatography , composite material , metallurgy
Abstract 9‐Hydroxyfluorenes are easily synthesized via a tandem Suzuki/phenolic aldolisation sequence. This process was extended to 9‐aminofluorenes by simply adding various amines as third partners. X‐ray structures and NMR studies confirmed the presence of intermolecular O−H ⋅ ⋅ ⋅ N hydrogen bonding.