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Nickel‐Catalyzed Denitrogenative Annulation of 1,2,3‐Benzotriazin‐4‐(3 H )‐ones with Benzynes for Construction of Phenanthridinone Scaffolds
Author(s) -
Thorat Vijaykumar H.,
Upadhyay Nitinkumar Satyadev,
Murakami Masahiro,
Cheng ChienHong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701143
Subject(s) - annulation , aryne , chemistry , catalysis , nickel , product (mathematics) , combinatorial chemistry , medicinal chemistry , organic chemistry , geometry , mathematics
The synthesis of phenanthridinones via denitrogenative annulation of 1,2,3‐benzotriazin‐4‐(3 H )‐ones with arynes catalysed by Ni(0)/dppm was successfully developed. A variety of phenanthridinones were prepared in good to excellent yields. Based on this method, nature product, N‐methylcrinasidine, was synthesized.