Premium
Visible‐Light‐Promoted Alkylation of Indoles with Tertiary Amines by the Oxidation of a sp 3 C‐H Bond
Author(s) -
Ding Xuan,
Dong ChunLin,
Guan Zhi,
He YanHong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701131
Subject(s) - chemistry , rose bengal , indole test , alkylation , photosensitizer , photochemistry , visible spectrum , medicinal chemistry , catalysis , organic chemistry , physics , optoelectronics
A visible‐light driven reaction for the synthesis of 3‐arylmethyl indole derivatives using tertiary amines and indoles was first reported. Corresponding products were obtained with yields of up to 70%, and various functional groups on the indoles were well tolerated when Rose Bengal was used as a photosensitizer and air was used as a green oxidant under mild reaction conditions.