Metal‐Free Radical‐Triggered Selenosulfonation of 1,7‐Enynes for the Rapid Synthesis of 3,4‐Dihydroquinolin‐2(1 H )‐ones in Batch and Flow

A novel three‐component selenosulfonation of 1,7‐enynes with sulfinic acids and diphenyl diselenides for the formation of multifunctional 3,4‐dihydroquinolin‐2(1 H )‐ones was developed in batch and flow. This room‐temperature protocol provides a highly efficient approach to diverse selenosulfones in moderate to excellent yields and with a broad scope of substrates. It should provide a potential synthesis method for the construction of diverse and meaningful 3,4‐dihydroquinolin‐2(1 H )‐ones derivatives in the fields of pharmaceutical and biological chemistry. Additionally, an obvious acceleration (20 h to 43 s) was obtained under micro flow conditions.