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Three‐Component Thieno[2,3‐ b ]indole Synthesis from Indoles, Alkenes or Alkynes and Sulfur Powder under Metal‐Free Conditions
Author(s) -
Li Bin,
Ni Penghui,
Huang Huawen,
Xiao Fuhong,
Deng GuoJun
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701106
Subject(s) - chemistry , sulfur , indole test , dimethylformamide , brønsted–lowry acid–base theory , component (thermodynamics) , metal , organic chemistry , combinatorial chemistry , catalysis , medicinal chemistry , physics , solvent , thermodynamics
A Bronsted acid promoted three‐component synthesis of substituted thieno[2,3‐ b ]indole has been developed starting from indoles, alkenes or alkynes, and sulfur powder. N , N ‐Dimethylformamide plays an important role to convert the starting materials into the fused products. Various functional groups attached to substrates were well tolerated to afford the corresponding products in moderate to good yields under very simple reaction conditions.