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Acid/Base‐Co‐catalyzed Direct Oxidative α‐Amination of Cyclic Ketones: Using Molecular Oxygen as the Oxidant
Author(s) -
Li YiJin,
Zhang Lu,
Yan Na,
Meng XiangHe,
Zhao YuLong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701103
Subject(s) - chemistry , amination , molecular oxygen , catalysis , base (topology) , combinatorial chemistry , reductive amination , oxidative phosphorylation , intermolecular force , organic base , diamine , primary (astronomy) , organic chemistry , oxygen , molecule , mathematical analysis , biochemistry , physics , mathematics , astronomy
A novel acid/base‐co‐catalyzed direct intermolecular α‐amination of various cyclic ketones has been developed for the first time. The reaction employs molecular oxygen as the sole oxidant under metal‐free conditions. The reaction tolerates a wide range of various anilines, especially primary diamine derivatives, and provides a simple and efficient method for the constructions of α‐amino enones and benzodiazepine derivatives in a single step.
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