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Front Cover Picture: Site‐Selective Rhodium(III)‐Catalyzed C−H Amination of 7‐Azaindoles with Anthranils: Synthesis and Anticancer Evaluation (Adv. Synth. Catal. 20/2017)
Author(s) -
Jeon Mijin,
Park Jihye,
Dey Prasanta,
Oh Yongguk,
Oh Hyunjung,
Han Sangil,
Um Sung Hee,
Kim Hyung Sik,
Mishra Neeraj Kumar,
Kim In Su
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701100
Subject(s) - chemistry , amination , rhodium , catalysis , front cover , stereochemistry , aryl , medicinal chemistry , combinatorial chemistry , cover (algebra) , organic chemistry , mechanical engineering , alkyl , engineering
The front cover picture , provided by Kim, Mishra and co‐workers, illustrates the synthetic strategy for the formation of ortho ‐aminated N ‐aryl‐7‐azaindoles based on the rhodium(III)‐ or iridium(III)‐catalyzed C−H functionalization using anthranils and azides. The synthesized 7‐azaindoles were readily transformed into biologically relevant azaindoloacridines, azaindoloacridones, and bis‐indoles. Notably, all synthetic products were evaluated for anticancer activity against human breast adenocarcinoma cells, human renal carcinoma cells, and human prostate adenocarcinoma cells. Some of 7‐azaindole derivatives displayed potent cytotoxicity competitive with anticancer doxorubicin. Details can be found in the communication on pages 3471–3478 (M. Jeon, J. Park, P. Dey, Y. Oh, H. Oh, S. Han, S. H. Um, H. S. Kim, N. K. Mishra, I. S. Kim, Adv. Synth. Catal . 2017 , 359 , 3471–3478; DOI 10.1002/adsc.201700800).