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Palladium‐Catalyzed [5+1] Annulation of 2‐(1‐Arylvinyl) Anilines and α‐Diazocarbonyl Compounds toward Multi‐functionalized Quinolines
Author(s) -
Zhu Jiawei,
Hu Weiming,
Sun Song,
Yu JinTao,
Cheng Jiang
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701069
Subject(s) - chemistry , annulation , palladium , intramolecular force , diazo , catalysis , decarboxylation , carbene , enol , organic chemistry , medicinal chemistry , alkyl , combinatorial chemistry
A palladium‐catalyzed [5+1] annulation of 2‐(1‐arylvinyl) anilines and α‐diazocarbonyl compounds has been developed, affording a series of multi‐functionalized quinolines in moderate to good yields. This procedure proceeded with the sequential insertion of N−H bond to the palladium carbene, intramolecular Heck reaction and decarboxylation steps. In this reaction, alkyl 2‐diazophenylacetates served as C1 building block, which represents a key compliment to diazo chemistry.