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Recent Progress in Organocatalytic Asymmetric Domino Transformations
Author(s) -
Chanda Tanmoy,
Zhao John C.G.
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701059
Subject(s) - domino , chemistry , organocatalysis , cascade reaction , biochemical engineering , enantioselective synthesis , domino effect , nanotechnology , organic synthesis , sustainability , combinatorial chemistry , catalysis , organic chemistry , engineering , materials science , ecology , physics , nuclear physics , biology
Sustainability in chemical synthesis is a major aspect of the current synthetic endeavors and, therefore, mimicking the biological process in the laboratory nowadays has the highest priority. Towards achieving this goal, designing organic reactions in domino mode rather than the multistep synthetic pathways and using organocatalysis instead of metal catalysis have received a lot of attention due to the inherent advantages of these processes in terms of synthetic efficiency and sustainability. As a result, the field of asymmetric organocatalytic domino reactions has witnessed tremendous progress in recent years. This review attempts to summarize the latest developments in asymmetric organocatalyzed domino reactions since 2012, with the emphasis on the catalysts and reaction modes. Discussions on the reaction mechanisms and the applications of the developed domino reaction methods in the synthesis of biologically active molecules and natural products are also included when appropriate.