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Efficient Cobalt‐Catalyzed Methylation of Amines Using Methanol
Author(s) -
Liu Zhenghui,
Yang Zhenzhen,
Yu Xiaoxiao,
Zhang Hongye,
Yu Bo,
Zhao Yanfei,
Liu Zhimin
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701044
Subject(s) - chemistry , methylamines , methanol , catalysis , cobalt , methylation , phosphine , ligand (biochemistry) , combinatorial chemistry , organic chemistry , receptor , biochemistry , gene
The methylation of amines using methanol is a promising route to synthesize N‐methylamines, and the development of cheap and efficient catalytic system for this reaction is of great significance. Herein, we reported a cobalt (Co)‐based catalytic system, which was in situ formed from commercially available Co precursor and a tetradentate phosphine ligand P(CH 2 CH 2 PPh 2 ) 3 combined with K 3 PO 4 . This catalystic system was very effective for the selective production of dimethylated products from aliphatic amines and monomethylated ones from aromatic amines. The reaction mechanism was further investigated by control and isotope labelling experiments.