Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of ( Z )‐ α ‐Hydroxymethyl Allylic Sulfones | Zendy

Hou Yunlei | Zendy; Shen Qi | Zendy; Li Zefei | Zendy; Chen Shaowei | Zendy; Zhao Yanfang | Zendy; Qin Mingze | Zendy; Gong Ping | Zendy

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Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of ( Z )‐ α ‐Hydroxymethyl Allylic Sulfones

Author(s) -

Hou Yunlei,

Shen Qi,

Li Zefei,

Chen Shaowei,

Zhao Yanfang,

Qin Mingze,

Gong Ping

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201701011

Subject(s) - chemistry , stereoselectivity , tandem , allylic rearrangement , aryl , catalysis , hydroxymethyl , palladium , sulfonyl , combinatorial chemistry , selectivity , cascade reaction , sulfone , organic chemistry , materials science , alkyl , composite material

A novel method is reported for the stereoselective synthesis of highly functionalized allyl aryl sulfones. This protocol is based on a Pd‐catalyzed three‐component tandem reaction of sulfonyl hydrazides and aryl iodides with allenes and exhibits high ( Z )‐selectivity, good yields, minimal waste, ample product scope, and operational simplicity.

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