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Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of ( Z )‐ α ‐Hydroxymethyl Allylic Sulfones
Author(s) -
Hou Yunlei,
Shen Qi,
Li Zefei,
Chen Shaowei,
Zhao Yanfang,
Qin Mingze,
Gong Ping
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701011
Subject(s) - chemistry , stereoselectivity , tandem , allylic rearrangement , aryl , catalysis , hydroxymethyl , palladium , sulfonyl , combinatorial chemistry , selectivity , cascade reaction , sulfone , organic chemistry , materials science , alkyl , composite material
Abstract A novel method is reported for the stereoselective synthesis of highly functionalized allyl aryl sulfones. This protocol is based on a Pd‐catalyzed three‐component tandem reaction of sulfonyl hydrazides and aryl iodides with allenes and exhibits high ( Z )‐selectivity, good yields, minimal waste, ample product scope, and operational simplicity.