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Palladium‐catalyzed Oxa‐[4+2] Annulation of para ‐Quinone Methides
Author(s) -
Yuan Zhenbo,
Pan Rui,
Zhang He,
Liu Lina,
Lin Aijun,
Yao Hequan
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700978
Subject(s) - annulation , chemistry , palladium , nucleophile , catalysis , quinone , alcohol , conjugated system , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , polymer
A palladium‐catalyzed oxa‐[4+2] annulation of para ‐quinone methides with allyl carbonates bearing a nucleophilic alcohol side chain has been developed. This method provided an efficient strategy to the construction of 2‐oxaspiro‐cyclohexadienones via 1,6‐conjugated addition‐mediated allylation in moderate to good yields. Preliminary results on asymmetric derivatives promised potential in the synthesis of enantioenriched frameworks.