Copper‐Mediated Thiolation of Unactivated Heteroaryl C−H Bonds with Disulfides under Ligand‐ and Metal‐Oxidant‐Free Conditions | Zendy

Li Ya | Zendy; Liu YueJin | Zendy; Shi BingFeng | Zendy

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Copper‐Mediated Thiolation of Unactivated Heteroaryl C−H Bonds with Disulfides under Ligand‐ and Metal‐Oxidant‐Free Conditions

Author(s) -

Li Ya,

Liu YueJin,

Shi BingFeng

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700949

Subject(s) - isopropylamine , chemistry , functional group , ligand (biochemistry) , amine gas treating , combinatorial chemistry , copper , metal , substrate (aquarium) , organic chemistry , biochemistry , receptor , oceanography , geology , polymer

Various sulfenylated heteroarenes were synthesized by a copper‐mediated C−H thiolation, which was assisted by a 2‐(pyridin‐2‐yl)isopropylamine (PIP‐amine) directing group. The reaction features a broad substrate scope, good functional group tolerance, ligand‐ and metal‐oxidant‐free conditions, exceptional compatibility with aliphatic disulfides, and excellent yields, providing a highly efficient approach to the biologically important sulfenylated heteroarenes.

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