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Organocatalytic Asymmetric Synthesis of Six‐Membered Carbocycle‐Based Spiro Compounds
Author(s) -
Xie Xin,
Huang Wei,
Peng Cheng,
Han Bo
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700927
Subject(s) - chemistry , stereocenter , organocatalysis , stereochemistry , enantioselective synthesis , stereoselectivity , tandem , molecule , combinatorial chemistry , ring (chemistry) , structural motif , cascade reaction , catalysis , organic chemistry , biochemistry , materials science , composite material
Well‐developed asymmetric organocatalysis has been widely incorporated in various cascade/tandem sequences, providing a simple access to structurally complex target molecules in a highly stereoselective fashion, including spirocyclic compounds. Among all types of spirocyclic skeletons, those containing a six‐membered carbocyclic ring are recognized as an important core framework with up to six consecutive stereogenic centers and this motif is commonly found in many natural products, biologically active molecules and lead compounds. This review describes the asymmetric synthesis of spirocyclic compounds containing six‐membered carbocycles using small organic molecules as catalysts.