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Copper‐Catalyzed Radical Silylarylation of Ynones with Silanes: En Route to Silyl‐Functionalized Indenones
Author(s) -
Yan Zhongfei,
Xie Jin,
Zhu Chengjian
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700926
Subject(s) - silanes , chemistry , silylation , catalysis , combinatorial chemistry , selectivity , hydrogen peroxide , peroxide , copper , organic chemistry , yield (engineering) , silane , materials science , metallurgy
A copper‐catalyzed radical silylarylation of ynones with commercially available silanes using DCP (dicumyl peroxide) as an efficient oxidant has been developed. This approach represents an efficient route to silyl‐functionalized indenone derivatives in moderate to good yield. The resulting silyl‐functionalized structures hold potential for further post‐modification to construct complex target molecules. This protocol is distinguished by its excellent selectivity, gram scale‐up ability and broad scope as well as readily available starting materials.