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Chiral Magnesium(II) Complex‐Catalyzed Enantioselective Desymmetrization of meso ‐Aziridines with Pyrazoles
Author(s) -
Li Xiangqiang,
Guo Jing,
Lin Lili,
Hu Haipeng,
Chang Fenzhen,
Liu Xiaohua,
Feng Xiaoming
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700888
Subject(s) - desymmetrization , enantioselective synthesis , chemistry , catalysis , yield (engineering) , pyrazole , magnesium , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy
A highly enantioselective catalytic protocol for the desymmetrization of meso ‐aziridines via ring‐opening with pyrazoles is reported using an N,N ′‐dioxide‐Mg(OTf) 2 complex as the catalyst. The corresponding trans ‐α‐pyrazole‐substituted amines were obtained in good yields and enantioselectivities (up to 99% yield and 94% ee ) under mild reaction conditions. Moreover, a remarkably high asymmetric amplification was observed in the catalytic system.
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