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Palladium Catalyzed C−C and C−N Bond Formation via ortho C−H Activation and Decarboxylative Strategy: A Practical Approach towards N ‐Acylated Indoles
Author(s) -
Kumar Saurabh,
Singh Rahul,
Singh Krishnd
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700872
Subject(s) - chemistry , palladium , catalysis , indole test , decarboxylation , ring (chemistry) , combinatorial chemistry , atom economy , medicinal chemistry , stereochemistry , organic chemistry
A concerted palladium catalyzed C−H activation and decarboxylative strategy has been explored for the efficient synthesis of N ‐acylated indoles. The process allows a facile step‐ and atom‐economic assembly of 3‐arylated indole ring from inexpensive and readily available anilides and cinnamic acids as reacting partners.