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Oxidative Phosphorylation of N ‐Aryl Glycine Amides via sp 3 C−H Functionalization
Author(s) -
Jia Xiaodong,
Liu Xiaofei,
Shao Yu,
Yuan Yu,
Zhu Yingzu,
Hou Wentao,
Zhang Xuewen
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700850
Subject(s) - chemistry , surface modification , oxidative phosphorylation , glycine , phosphorylation , nucleophile , aryl , salt (chemistry) , radical , functional group , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry , amino acid , alkyl , polymer
An efficient phosphorylation of various glycine amides has been developed for radical cation salt‐induced C−H functionalization, producing a series of α‐aminophosphonates in high yields. Different from reported approaches, trialkyl phosphite was chosen as the phosphorus nucleophile, and the scope investigation shows broad functional group tolerance and high efficiency of the oxidative phosphorylation. This method provides a new way to synthesize α‐aminophosphonates.