Premium
The Synthesis of Chiral α‐Aryl α‐Hydroxy Carboxylic Acids via RuPHOX‐Ru Catalyzed Asymmetric Hydrogenation
Author(s) -
Guo Huan,
Li Jing,
Liu Delong,
Zhang Wanbin
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700846
Subject(s) - chemistry , oxazoline , ruthenium , aryl , catalysis , enantioselective synthesis , asymmetric hydrogenation , combinatorial chemistry , organic chemistry , optically active , noyori asymmetric hydrogenation , alkyl
A ruthenocenyl phosphino‐oxazoline‐ruthenium complex (RuPHOX−Ru) catalyzed asymmetric hydrogenation of α‐aryl keto acids has been successfully developed, affording the corresponding chiral α‐aryl α‐hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs.