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Iron‐Catalyzed C( sp 3 )−C( sp 3 ) Bond Formation in 3,4‐Dihydro‐1,4‐benzoxazin‐2‐ones
Author(s) -
Dong Jie,
Min Wenjian,
Li Haitao,
Quan Zhengjun,
Yang Caixia,
Huo Congde
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700816
Subject(s) - chemistry , catalysis , alkyl , medicinal chemistry , transformation (genetics) , coupling reaction , organic chemistry , biochemistry , gene
A convenient iron‐catalyzed oxidative dehydrogenative coupling reaction of 3,4‐Dihydro‐1,4‐benzoxazin‐2‐ones with malonic esters or ketones was performed under mild reaction conditions to construct alkyl–alkyl C( sp 3 )−C( sp 3 ) bonds. This transformation can be catalyzed efficiently by magnetically recoverable iron nanoparticles and the catalyst can be recycled easily for 7 times without decreasing activity.