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Copper‐Catalyzed Decarboxylative Alkylation of Terminal Alkynes
Author(s) -
Ye Changqing,
Li Yajun,
Bao Hongli
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700798
Subject(s) - chemistry , alkylation , alkyl , catalysis , aryl , decarboxylation , copper , alkyne , terminal (telecommunication) , organic chemistry , medicinal chemistry , telecommunications , computer science
A copper‐catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C( sp 3 )−C( sp ) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway.