Copper‐Catalyzed Decarboxylative Alkylation of Terminal Alkynes | Zendy

Ye Changqing | Zendy; Li Yajun | Zendy; Bao Hongli | Zendy

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Copper‐Catalyzed Decarboxylative Alkylation of Terminal Alkynes

Author(s) -

Ye Changqing,

Li Yajun,

Bao Hongli

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700798

Subject(s) - chemistry , alkylation , alkyl , catalysis , aryl , decarboxylation , copper , alkyne , terminal (telecommunication) , organic chemistry , medicinal chemistry , telecommunications , computer science

A copper‐catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C( sp 3 )−C( sp ) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway.

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