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Iridium(III)‐Catalyzed Selective and Mild C‐H Amidation of Cyclic N ‐Sulfonyl Ketimines with Organic Azides
Author(s) -
Maraswami Manikantha,
Chen Gang,
Loh TeckPeng
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700785
Subject(s) - sulfonyl , chemistry , regioselectivity , iridium , aryl , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
Abstract A general protocol for iridium catalyzed direct C−H amidation of cyclic N ‐sulfonyl ketimines using sulfonyl, acyl and aryl azides as nitrogen source is reported herein. The reaction takes place at room temperature with acyl and aryl azides, while an elevated temperature needed with sulfonyl azides to furnish aminated sultams in excellent yields with complete chemo and regioselectivity, thus providing a robust and environmentally benign process to the synthesis of aminosultams.