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Traceless Directing Group Assisted Cobalt‐Catalyzed C−H Carbonylation of Benzylamines
Author(s) -
Ling Fei,
Ai Chongren,
Lv Yaping,
Zhong Weihui
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700780
Subject(s) - chemistry , carbonylation , catalysis , cobalt , combinatorial chemistry , functional group , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry , carbon monoxide , polymer
The first example of cobalt‐catalyzed C( sp 2 )−H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N −unprotected iso‐indolinones through direct C−H/N−H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)‐garenoxacin.