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Tandem Cross Coupling Reaction of Alcohols for Sustainable Synthesis of β‐Alkylated Secondary Alcohols and Flavan Derivatives
Author(s) -
Shee Sujan,
Paul Bhaskar,
Panja Dibyajyoti,
Roy Bivas Chandra,
Chakrabarti Kaushik,
Ganguli Kasturi,
Das Ayan,
Das Gourab Kanti,
Kundu Sabuj
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700722
Subject(s) - chemistry , tandem , catalysis , flavan , reactivity (psychology) , alkylation , organic chemistry , coupling reaction , primary (astronomy) , combinatorial chemistry , medicine , materials science , alternative medicine , pathology , composite material , physics , astronomy
A Ru(II) NHC complex (loading down to 0.001 mol%) catalyzed cross coupling of a broad range of aromatic, aliphatic and heterocyclic alcohols is reported. This protocol also functioned efficiently under solvent‐free conditions. Remarkably, this catalytic system disclosed so far the highest TON of 288000 for the cross coupling of alcohols. Notably, this methodology was successfully applied for the one‐pot synthesis of a range of flavan derivatives. A detailed DFT studies and kinetic experiments were performed to understand the reaction mechanism as well as the high reactivity of this catalytic system.