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Metal‐Free Annulation Cascades of 1,7‐Enynes Using Di‐ tert ‐butyl Peroxide as the Methyl Source towards the Synthesis of Polyheterocyclic Scaffolds
Author(s) -
Tan FangLin,
Hu Ming,
Song RenJie,
Li JinHeng
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700699
Subject(s) - chemistry , annulation , peroxide , combinatorial chemistry , benzoyl peroxide , radical , benzene , methylation , medicinal chemistry , catalysis , stereochemistry , organic chemistry , monomer , biochemistry , gene , polymer
A new metal‐free oxidative cascade methylation/cyclization of benzene‐linked 1,7‐enynes to construct methylated polyheterocyclic scaffold skeletons is described. In this transformation, three new C–C bonds and two new rings are formed. Notably, di‐ tert ‐butyl peroxide (DTBP) acts not only as a radical initiator but also as an efficient methyl source.