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A General and Practical Approach for the Synthesis of 1,2,4‐Trioxanes Catalyzed by Silica‐Ferric Chloride
Author(s) -
Zhang Mo,
Han Yi,
Niu JiaLiang,
Zhang ZhanHui
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700671
Subject(s) - chemistry , ferric , catalysis , chloride , condensation , filtration (mathematics) , combinatorial chemistry , organic chemistry , physics , statistics , mathematics , thermodynamics
An efficient and practical method has been developed for the facile synthesis of 1,2,4‐trioxanes by the condensation of β‐hydroperoxy alcohols and carbonyl compounds in the presence of a catalytic amount of silica‐supported ferric chloride (FeCl 3 /SiO 2 ) at room temperature. The method has the benefits of operational simplicity, high yields and potential large‐scale application. Moreover, the catalyst can be readily recovered by simple filtration and reused up to five times while almost maintaining its catalytic activity.