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Secondary Phosphine Oxide Preligands for Palladium‐Catalyzed C–H (Hetero)Arylations: Efficient Access to Pybox Ligands
Author(s) -
Ghorai Debasish,
Müller Valentin,
Keil Helena,
Stalke Dietmar,
Zai Giuseppe,
Tkachenko Boryslav A.,
Schreiner Peter R.,
Ackermann Lutz
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700663
Subject(s) - chemistry , palladium , racemization , aryl , phosphine , phosphine oxide , catalysis , oxide , combinatorial chemistry , organic chemistry , alkyl
C–H arylations of oxazolines were accomplished with a well‐defined palladium catalyst derived from a secondary bisdiamantyl phosphine oxide. The single‐component secondary phosphine oxide (SPO)‐palladium complex enabled C–H activations with aryl bromides and challenging aryl chlorides in the absence of directing groups, setting the stage for the step‐economical synthesis of pybox ligands under racemization‐free reaction conditions.