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Front Cover Picture: A Polystyrene‐Supported Phase‐Transfer Catalyst for Asymmetric Michael Addition of Glycine‐Derived Imines to α,β‐Unsaturated Ketones (Adv. Synth. Catal. 17/2017)
Author(s) -
Miguélez Javier,
Miyamura Hiroyuki,
Kobayashi Shū
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700625
Subject(s) - chemistry , catalysis , front cover , michael reaction , glycine , polystyrene , polymer chemistry , organic chemistry , polymer , cover (algebra) , amino acid , mechanical engineering , biochemistry , engineering
The front cover picture , provided by Shū Kobayashi and co‐workers, illustrates a polymer immobilized chiral 2‐oxopyrimidinium salt for asymmetric Michael addition of glycine‐derived imines to α,β‐unsaturated ketones. The reaction proceeded smoothly with 5 mol % of the heterogeneous catalyst and the products were obtained with good to excellent enantioselectivities. Interestingly, the addition of polydimethylsilane to the chiral heterogeneous catalyst greatly improved the ease of handling of the catalyst and the thus prepared composite catalyst could be recovered and reused several times, keeping activity and enantioselectivity. Details can be found in the communication on pages 2897–2900 (J. Miguélez, H. Miyamura, S. Kobayashi, Adv. Synth. Catal . 2017 , 359 , 2897–2900; DOI 10.1002/adsc.201700155).