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Front Cover Picture: Hydrogen Bonding‐Assisted Enhancement of the Reaction Rate and Selectivity in the Kinetic Resolution of d,l ‐1,2‐Diols with Chiral Nucleophilic Catalysts (Adv. Synth. Catal. 16/2017)
Author(s) -
Fujii Kazuki,
Mitsudo Koichi,
Mandai Hiroki,
Suga Seiji
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700620
Subject(s) - chemistry , catalysis , nucleophile , kinetic resolution , diol , front cover , selectivity , cover (algebra) , polymer chemistry , organic chemistry , enantioselective synthesis , mechanical engineering , engineering
The front cover image , provided by Kazuki Fujii, Hiroki Mandai, and Seiji Suga, illustrates the large scale (10 g) kinetic resolution of d,l ‐hydrobenzoin with a highly active nucleophilic catalyst. The catalyst well recognizes the diol unit and accelerates only the monoacylation reaction. The reaction proceeds with only 0.1 mol% of the catalyst within 30 min, and both the monoacylate and the recovered diol are obtained with high enantioselectivities. The acceleration effect by the catalyst is portrayed by the tachometer in the picture. Details can be found in the full paper on pages 2778–2788 (K. Fujii, K. Mitsudo, H. Mandai, S. Suga, Adv. Synth. Catal . 2017 , 359 , 2778–2788; DOI: 10.1002/adsc.201700057).