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A Visible‐Light‐Driven, Metal‐free Route to Aromatic Amides via Radical Arylation of Isonitriles
Author(s) -
Malacarne Marco,
Protti Stefano,
Fagi Maurizio
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700619
Subject(s) - chemistry , acetonitrile , radical , aryl , moclobemide , photochemistry , visible spectrum , aqueous solution , metal , combinatorial chemistry , organic chemistry , antidepressant , alkyl , physics , optoelectronics , neuroscience , biology , hippocampus
The photochemical metal‐free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including hetero‐ and polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide.