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Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di‐ and Mono‐Fluorinated Alkyl Nitriles
Author(s) -
Ren Rongguo,
Wu Zhen,
Huan Leitao,
Zhu Chen
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700591
Subject(s) - chemistry , alkyl , intramolecular force , photocatalysis , photoredox catalysis , catalysis , combinatorial chemistry , organic chemistry , halogenation
A general protocol for the challenging cyanofluoroalkylation of unactivated alkenes is disclosed. A broad range of synthetically useful di‐ and mono‐fluorinated alkyl nitriles are readily obtained in good yields under mild reaction conditions. The efficient combination of intramolecular cyano migration and photoredox catalysis significantly expands the field of difunctionalization of olefins.