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Copper‐Catalyzed Aminodifluoroalkylation of Alkenes with α‐Bromodifluoroacetamides: Synthesis of 3,3‐Difluoropyrrolidin‐2‐ones
Author(s) -
Lv Yunhe,
Pu Weiya,
Wang Qingqing,
Chen Qian,
Niu Jiejie,
Zhang Qian
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700559
Subject(s) - chemistry , regioselectivity , copper , catalysis , functional group , combinatorial chemistry , alkene , organic chemistry , polymer
Copper‐catalyzed external‐oxidant‐free regioselective aminodifluoroalkylation of alkenes with readily available α‐bromodifluoroacetamides was realized. This reaction exhibits good functional group tolerance with respect to alkenes and α‐bromodifluoroacetamides in affording 3,3‐difluoropyrrolidin‐2‐ones. A mechanism involving copper‐catalyzed generation of a difluoroalkyl radical is proposed.