Copper‐Catalyzed Aminodifluoroalkylation of Alkenes with α‐Bromodifluoroacetamides: Synthesis of 3,3‐Difluoropyrrolidin‐2‐ones | Zendy

Lv Yunhe | Zendy; Pu Weiya | Zendy; Wang Qingqing | Zendy; Chen Qian | Zendy; Niu Jiejie | Zendy; Zhang Qian | Zendy

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Copper‐Catalyzed Aminodifluoroalkylation of Alkenes with α‐Bromodifluoroacetamides: Synthesis of 3,3‐Difluoropyrrolidin‐2‐ones

Author(s) -

Lv Yunhe,

Pu Weiya,

Wang Qingqing,

Chen Qian,

Niu Jiejie,

Zhang Qian

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700559

Subject(s) - chemistry , regioselectivity , copper , catalysis , functional group , combinatorial chemistry , alkene , organic chemistry , polymer

Copper‐catalyzed external‐oxidant‐free regioselective aminodifluoroalkylation of alkenes with readily available α‐bromodifluoroacetamides was realized. This reaction exhibits good functional group tolerance with respect to alkenes and α‐bromodifluoroacetamides in affording 3,3‐difluoropyrrolidin‐2‐ones. A mechanism involving copper‐catalyzed generation of a difluoroalkyl radical is proposed.

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