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Synthesis of Tetrasubstituted α,β‐Unsaturated Aldehydes via Radical 1,4‐Aryl Migration/Trifluoromethylthiolation Cascade Reaction of Aryl Propynyl Ethers
Author(s) -
Guo ChunHuan,
Chen DaoQian,
Chen Si,
Liu XueYuan
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700534
Subject(s) - propynyl , chemistry , aryl , trifluoromethyl , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
A one‐pot synthesis of tetrasubstituted acrylaldehydes via difunctionalization of aryl propynyl ethers has been achieved, which involves a trifluoromethylthiolation process and a radical 1,4‐aryl migration from oxygen to carbon. The reaction shows excellent conversion of aryl propynyl ethers into trifluoromethyl‐containing α,β‐unsaturated aldehydes through a radical pathway.

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