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Palladium‐Catalyzed Cross‐Coupling of Alkynyl Carboxylic Acids with Isocyanides: Solvent‐Controlled Selective Synthesis of 5‐Iminofuranones and 5‐Iminopyrrolones
Author(s) -
Hu Weigao,
Li Zun,
Li Jiawei,
Wu Wanqing,
Liu Haiyang,
Jiang Huanfeng
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700533
Subject(s) - chemistry , palladium , catalysis , substrate (aquarium) , combinatorial chemistry , solvent , organic chemistry , palladium catalyst , isocyanide , oceanography , geology
A novel palladium‐catalyzed cyclization of alkynyl carboxylic acids with isocyanides has been successfully developed herein. The corresponding 5‐iminofuranone or 5‐iminopyrrolone derivatives were constructed in moderate to good yields which were well controlled by the solvents. These reactions proceed under simple and mild reaction conditions with high efficiency, and feature a wide substrate scope, readily available starting materials and easy operation.