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Transition Metal‐Free Oxidative Cross‐Coupling C( sp 2 )–C( sp 3 ) Bond Formation: Regioselective C‐3 Alkylation of Coumarins with Tertiary Amines
Author(s) -
Dian Longyang,
ZhangNegrerie Daisy,
Du Yunfei
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700521
Subject(s) - regioselectivity , chemistry , alkylation , transition metal , catalysis , oxidative coupling of methane , metal , medicinal chemistry , stereochemistry , organic chemistry
A novel transition‐metal‐free regioselective C‐3 alkylation of coumarins was realized under mild reaction conditions. Various coumarins and tertiary amines smoothly underwent direct C( sp 2 )–C( sp 3 ) bond formation in the presence of ( n‐ Bu) 4 NI as the catalyst and t‐ BuOOH as the oxidant.
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