Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr 2 /NIXANTPHOS‐based Catalyst | Zendy

Gao Gui | Zendy; Fu Yue | Zendy; Li Minyan | Zendy; Wang Bo | Zendy; Zheng Bing | Zendy; Hou Shicong | Zendy; Walsh Patrick J. | Zendy

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Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr 2 /NIXANTPHOS‐based Catalyst

Author(s) -

Gao Gui,

Fu Yue,

Li Minyan,

Wang Bo,

Zheng Bing,

Hou Shicong,

Walsh Patrick J.

Publication year - 2017

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201700438

Subject(s) - chemistry , aryl , methylamine , catalysis , yield (engineering) , nickel , reactivity (psychology) , combinatorial chemistry , organic chemistry , metallurgy , medicine , alkyl , materials science , alternative medicine , pathology

A nickel‐catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr 2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield).

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