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Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr 2 /NIXANTPHOS‐based Catalyst
Author(s) -
Gao Gui,
Fu Yue,
Li Minyan,
Wang Bo,
Zheng Bing,
Hou Shicong,
Walsh Patrick J.
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700438
Subject(s) - chemistry , aryl , methylamine , catalysis , yield (engineering) , nickel , reactivity (psychology) , combinatorial chemistry , organic chemistry , metallurgy , medicine , alkyl , materials science , alternative medicine , pathology
A nickel‐catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr 2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield).