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Enantioselective Hydrogenation of Pyrrolo[1,2‐ a ]pyrazines, Heteroaromatics Containing Two Nitrogen Atoms
Author(s) -
Hu ShuBo,
Chen ZhangPei,
Song Bo,
Wang Jie,
Zhou YongGui
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700431
Subject(s) - enantioselective synthesis , chemistry , iridium , nitrogen , optically active , asymmetric hydrogenation , catalysis , combinatorial chemistry , nitrogen atom , organic chemistry , stereochemistry , ring (chemistry)
Abstract An enantioselective iridium‐catalyzed direct hydrogenation of heteroaromatics containing two nitrogen atoms, 3‐substituted pyrrolo[1,2‐ a ]pyrazines, has been successfully achieved, providing a facile synthesis of optically active 1,2,3,4‐tetrahydropyrrolo[1,2‐ a ]pyrazines with up to 96% ee .

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