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Intramolecular Hydroamidation of ortho ‐Vinyl Benzamides Promoted by Potassium tert ‐Butoxide/ N,N ‐Dimethylformamide
Author(s) -
Chen Zhenyu,
Wu Liangyu,
Fang Haisheng,
Zhang Ting,
Mao Zhifeng,
Zou Yong,
Zhang Xuejing,
Yan Ming
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700369
Subject(s) - chemistry , intramolecular force , dimethylformamide , catalysis , potassium , medicinal chemistry , transition metal , organic chemistry , combinatorial chemistry , solvent
An intramolecular hydroamidation of ortho ‐vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert ‐butoxide and N,N ‐dimethylformamide without the need for strong oxidants or transition‐metal catalysts. A series of dihydroisoquinolinones and 3‐benzylisoindolinones were prepared in good to excellent yields. The new method is operationally simple, scalable, and tolerant of various functional groups.