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Copper‐Catalyzed Intermolecular Aminoalkylation of Alkenes with α‐Bromoalkyl Esters and Amines toward Pyrrolidin‐2‐ones
Author(s) -
Pan GaoHui,
Ouyang XuanHui,
Hu Ming,
Xie YeXiang,
Li JinHeng
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700365
Subject(s) - annulation , chemistry , catalysis , intermolecular force , tandem , copper , primary (astronomy) , organic chemistry , medicinal chemistry , molecule , materials science , physics , astronomy , composite material
We here describe a new copper‐catalyzed tandem annulation of alkenes with α‐bromoalkyl esters and primary amines for producing polysubstituted pyrrolidin‐2‐ones. The reaction allows the formation of three new chemical bonds, one C–C bond and two C–N bonds, in a single reaction, and represents the first three‐component difunctionalization of alkenes for the synthesis of pyrrolidin‐2‐ones involving [2+2+1] annulation.