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Cascade One‐Pot Synthesis of Indanone‐Fused Cyclopentanes from the Reaction of Donor‐Acceptor Cyclopropanes and Enynals via a Sequential Hydrolysis/Knoevenagel Condensation/[3+2] Cycloaddition
Author(s) -
Zhang Jiantao,
Jiang Huanfeng,
Zhu Shifa
Publication year - 2017
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201700345
Subject(s) - chemistry , cyclopentanes , knoevenagel condensation , cycloaddition , cascade reaction , moiety , organic chemistry , hydrolysis , cyclopentane , combinatorial chemistry , catalysis
A cascade reaction of donor‐acceptor cyclopropanes with enynals to construct indanone‐fused cyclopentanes via a sequential hydrolysis/Knoevenagel condensation/[3+2] cycloaddition is reported. The desired indanone‐fused cyclopentanes were obtained in good yields. This method features mild reaction conditions and broad substrate scope, which render it very appealing to chemists for the synthesis of complex molecules containing an indanone‐fused cyclopentane moiety. Moreover, the products could be further converted into compounds with different functional groups through the well‐known transformations.